Tretinoin

The gold standard prescription retinoid

Prescription tretinoin (0.025%–0.1%) applied every other night builds to nightly use. Unlike over-the-counter retinol, tretinoin binds directly to retinoic acid receptors without conversion — delivering collagen induction, acne clearance, and hyperpigmentation reversal at a speed no OTC product can match. Dermatologists call it the most evidence-backed topical in existence.