Berberine

Nature's metformin for blood sugar and skin

500mg of berberine taken with meals, 2–3x daily. Berberine activates AMPK (the same pathway as metformin), improving insulin sensitivity and reducing post-meal blood sugar spikes. Lower insulin means less androgens, less sebum, and less inflammatory acne. Studies show berberine reduces fasting blood glucose comparably to metformin in type 2 diabetics — and its effects on skin clarity and body composition are a consistent secondary finding.